Experience

Over the past while, I've been reading about DMT, a relatively new, hallucinogenic drug that is quite popular right now.  The thing that is so intriguing about this stuff is the subtitle, "the spirit molecule."  It is strongly suggested/believed in the DMT circles that the ingestion of this naturally occurring drug opens one up to a different reality.  It is suggested that the drug reveals the foundational, universal reality behind and beneath the visual, temporal reality in which we currently live.
While I am not going to go into the validity of this argument, I do want to explore the idea of this experience.  There are many experiences that occur across the board.  So it is suggested that the experiences that people have are actually an objective reality. 
My question is this: in the living out of an experience like this, upon what do we base our interpretation of those experiences?  Because the things being experienced are from a different reality, we have nothing to which to compare them.  This is the real danger.  Because we are talking about a non temporal (spiritual) experience, the potential for deception is very high.  And beings or entities that one may meet in this kind of experience are going to be safe or dangerous.  They will be honest or they will lie.  And how can we know to trust them or not?  From a Christian perspective, one must presume that these beings are malevolent (demonic).
This is about presuppositions and worldview.  How do we interpret our experiences?